Closed and Open Loop Subspace System Identification of the Kalman Filter

Some methods for consistent closed loop subspace system identification presented in the literature are analyzed and compared to a recently published subspace algorithm for both open as well as for closed loop data, the DSR_e algorithm. Some new variants of this algorithm are presented and discussed. Simulation experiments are included in order to illustrate if the algorithms are variance efficient or not

Towards maintainer script modernization in FOSS distributions

Free and Open Source Software (FOSS) distributions are complex software systems, made of thousands packages that evolve rapidly, independently, and without centralized coordination. During packages upgrades, corner case failures can be encountered and are hard to deal with, especially when they are due to misbehaving maintainer scripts: executable code snippets used to finalize package configuration. In this paper we report a software modernization experience, the process of representing existing legacy systems in terms of models, applied to FOSS distributions. We present a process to define meta-models that enable dealing with upgrade failures and help rolling back from them, taking into account maintainer scripts. The process has been applied to widely used FOSS distributions and we report about such experiences

Improvement of BepiColombo's radio science experiment through an innovative Doppler noise reduction technique

The Mercury Orbiter Radio science Experiment (MORE), onboard the ESA/JAXA BepiColombo mission to Mercury, is designed to estimate Mercury’s gravity field, its rotational state, and to perform tests of relativistic gravity. The state-of-the-art onboard and ground instrumentations involved in the MORE experiment will enable to establish simultaneous X/X, X/Ka and Ka/Ka-band links, providing a range rate accuracy of 3 µm/s (at 1000 s integration time) and a range accuracy of 20 cm. The purpose of this work is to show the improvement achievable on MORE’s performance by means of the Time-Delay Mechanical Noise Cancellation (TDMC) technique. The TDMC consists in a combination of Doppler measurements collected (at different times) at the two-way antenna and at an additional, smaller and stiffer, receive-only antenna that should be located in a site with favorable tropospheric conditions. This configuration could reduce the leading noises in a Ka-band two-way link, such as those caused by troposphere and ground antenna mechanical vibrations. We present the results of end-to-end simulations and estimation of Mercury’s gravity field and rotational state considering the TDMC technique. We compare results for a two-way link from NASA’s DSS-25 (in Goldstone, CA) or from ESA’s DSA-3 (in Malargue, Argentina), while we assume APEX as the receive-only antenna. We show that in best-case noise conditions, the TDMC technique allows to obtain a factor-of-two accuracy gain on both global and local parameters, considering DSA-3 as two-way antenna. Such improvement in the scientific objectives of MORE is of geophysical interest as it could provide a constraint on the interior structure of Mercury

The Bright and Dark Side of DNA Methylation: A Matter of Balance

DNA methylation controls several cellular processes, from early development to old age, including biological responses to endogenous or exogenous stimuli contributing to disease transition. As a result, minimal DNA methylation changes during developmental stages drive severe phenotypes, as observed in germ-line imprinting disorders, while genome-wide alterations occurring in somatic cells are linked to cancer onset and progression. By summarizing the molecular events governing DNA methylation, we focus on the methods that have facilitated mapping and understanding of this epigenetic mark in healthy conditions and diseases. Overall, we review the bright (health-related) and dark (disease-related) side of DNA methylation changes, outlining how bulk and single-cell genomic analyses are moving toward the identification of new molecular targets and driving the development of more specific and less toxic demethylating agents

Improvements in BepiColombo and JUICE radio science experiments with a multi-station tracking configuration for the reduction of Doppler noise

Radio science experiments for planetary geodesy mostly rely on measurements of the Doppler shift of microwave signals sent to a spacecraft by an Earth station, and retransmitted back coherently in phase to the same antenna (two-way link). The retransmitted signal can also be received by a different station in a listen-only configuration (three-way link). In state-of-the-art tracking systems, such as the ones will be used on the future ESA's missions JUICE and BepiColombo, the Doppler error budget is dominated by local noise sources arising at the ground-station, in particular tropospheric scintillation and unmodeled motions of the antenna's structure. In this work, a novel technique aimed at reducing these disturbances is analyzed, with particular emphasis on its benefits to BepiColombo's and JUICE's radio science experiments. The method, referred to as Time-Delay Mechanical-noise Cancellation (TDMC), relies on simultaneous two-way and three-way spacecraft tracking, the latter employing a stiffer listen-only antenna with better mechanical stability and located in a favorable dry region more immune to tropospheric noise. In fact, a proper linear combination of time-shifted observables from the two-way and three-way links can replace local noises of the two-way ground-station with those coming from the listen-only antenna, translating into increased accuracy of the final measurements, while preserving the original Doppler content. We show the results of covariance analyses performed with a multi-arc weighted least square estimator for the entire BepiColombo's Hermean phase and JUICE's flybys of Callisto. We compare the two solutions obtained with and without the application of the TDMC technique. For BepiColombo and JUICE radio science experiments, the two-way links are baselined from the 35-m DSA-3 (Malargüe, Argentina) and the 34-m DSS 25 (Goldstone, California). For the three-way link, we select the 12-m Large Latin American Millimeter Array (LLAMA) antenna for three reasons: 1) its mechanical rigidity with respect to large beam-waveguide antennas, 2) its unique position in the extremely dry Puna de Atacama desert, that assures low tropospheric noise, and 3) its limited longitudinal separation from the two other ground-stations, granting sufficient common visibility time to perform the requested combination of the observables. Besides its noise-reduction effect, enabling unprecedented levels of accuracy on Doppler measurements, TDMC provides also a back-up for unique events: a crucial satellite flyby or a specific passage over a site of particular geophysical interest. Indeed, measurements become virtually independent of unfavorable meteorological conditions at the transmitting station